MOUSE MONOCLONAL ANTI-CYTOKERATIN

Application

Monoclonal Anti-Cytokeratin Peptide 13 antibody produced in mouse is suitable for the following applications: Immunohistochemistry (formalin-fixed, paraffin-embedded sections) Indirect immunofluorescence at a working dilution of 1:100 using formalin-fixed, paraffin-embedded human tissue sections. Microarray

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunofluorescence (1 paper)

Biochem/physiol Actions

Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

cultured human epidermoid carcinoma cell line A-431.

Specificity

The antibody reacts with squamous, non-keratinized epithelium, transitional epithelium, pseudostratified epithelium, and myoepithelium.